| 5 Sept 2021 | ND 135/6 v SV 117Semi-Final · T20 | Northern Diamonds won by 18 runs | Southampton | Charlotte Edwards Cup 2021 |
| 5 Sept 2021 | ND 138/4 v SES 139/5Final · T20 | South East Stars won by 5 wickets | Southampton | Charlotte Edwards Cup 2021 |
| 30 Aug 2021 | LIG 124/9 v SV 125/3Match · T20 | Southern Vipers won by 7 wickets | Derby | Charlotte Edwards Cup 2021 |
| 30 Aug 2021 | SES 165/6 v CS 139/6Match · T20 | South East Stars won by 26 runs | Birmingham | Charlotte Edwards Cup 2021 |
| 30 Aug 2021 | WS 147/5 v SUN 142/7Match · T20 | Western Storm won by 5 runs | Cambridge | Charlotte Edwards Cup 2021 |
| 30 Aug 2021 | THU 90/9 v ND 92/2Match · T20 | Northern Diamonds won by 8 wickets | Chester | Charlotte Edwards Cup 2021 |
| 28 Aug 2021 | LIG 136/8 v CS 139/6Match · T20 | Central Sparks won by 4 wickets | Worcester | Charlotte Edwards Cup 2021 |
| 28 Aug 2021 | SES 167/4 v SV 147/7Match · T20 | South East Stars won by 20 runs | Southampton | Charlotte Edwards Cup 2021 |
| 28 Aug 2021 | ND 110/9 v WS 111/6Match · T20 | Western Storm won by 4 wickets | Chester-le-Street | Charlotte Edwards Cup 2021 |
| 28 Aug 2021 | THU 124/5 v SUN 124/4Match · T20 | Match tied | Northampton | Charlotte Edwards Cup 2021 |
| 25 Aug 2021 | SES 175/6 v LIG 147/7Match · T20 | South East Stars won by 28 runs | Guildford | Charlotte Edwards Cup 2021 |
| 25 Aug 2021 | SV 162/4 v CS 163/4Match · T20 | Central Sparks won by 6 wickets | Brighton | Charlotte Edwards Cup 2021 |
| 25 Aug 2021 | ND 120/6 v SUN 101/7Match · T20 | Northern Diamonds won by 19 runs | Gosforth | Charlotte Edwards Cup 2021 |
| 25 Aug 2021 | THU 100/9 v WS 101/3Match · T20 | Western Storm won by 7 wickets | Cardiff | Charlotte Edwards Cup 2021 |
| 10 Jul 2021 | LIG 81 v CS 84/4Match · T20 | Central Sparks won by 6 wickets | Leicester | Charlotte Edwards Cup 2021 |
| 10 Jul 2021 | SES 127/7 v SV 130/3Match · T20 | Southern Vipers won by 7 wickets | Canterbury | Charlotte Edwards Cup 2021 |
| 10 Jul 2021 | WS 106/9 v ND 110/9Match · T20 | Northern Diamonds won by 1 wicket | Taunton | Charlotte Edwards Cup 2021 |
| 9 Jul 2021 | THU 186/1 v SUN 115Match · T20 | Thunder won by 71 runs | Manchester | Charlotte Edwards Cup 2021 |
| 4 Jul 2021 | THU 110/8 v WS 36/1Match · T20 | Western Storm won by 9 wickets (DLS method) | Chester | Charlotte Edwards Cup 2021 |
| 3 Jul 2021 | CS 117 v SES 118/5Match · T20 | South East Stars won by 5 wickets | Canterbury | Charlotte Edwards Cup 2021 |
| 3 Jul 2021 | SV 134/7 v LIG 88Match · T20 | Southern Vipers won by 46 runs | Arundel | Charlotte Edwards Cup 2021 |
| 2 Jul 2021 | SUN 116/7 v ND 117/2Match · T20 | Northern Diamonds won by 8 wickets | Chelmsford | Charlotte Edwards Cup 2021 |
| 26 Jun 2021 | LIG 107 v SES 108/4Match · T20 | South East Stars won by 6 wickets | Nottingham | Charlotte Edwards Cup 2021 |
| 26 Jun 2021 | CS 83 v SV 85/2Match · T20 | Southern Vipers won by 8 wickets | Birmingham | Charlotte Edwards Cup 2021 |
| 26 Jun 2021 | THU 118/6 v ND 106/9Match · T20 | Thunder won by 12 runs | Leeds | Charlotte Edwards Cup 2021 |
| 26 Jun 2021 | WS 129/6 v SUN 133/3Match · T20 | Sunrisers won by 7 wickets | Taunton | Charlotte Edwards Cup 2021 |
